Publications by authors named "S Neutzel"
Article Synopsis
- Recent research indicates that lineage-depleted murine hematopoietic stem cells can successfully engraft and repopulate secondary recipients after being transplanted into lethally irradiated mice.
- A study was conducted to assess if different rates of radiation delivery affected the homing of these stem cells to the bone marrow and other tissues, leading to findings that nearly all irradiated groups showed a significant reduction in stem cell homing compared to unirradiated controls.
- The results challenge the idea that radiation creates necessary "space" for stem cell homing in the bone marrow, suggesting that other factors may play a role in stem cell migration and engraftment.
Using an in vivo selection technique, we can isolate individual cells that can repopulate the hematopoietic system of a lethally irradiated murine recipient. These cells rapidly acquire a CD34 phenotype in the animal. Progenitors in our long-term chimeras are of donor type.
View Article and Find Full Text PDFPurification of rare hematopoietic stem cell(s) (HSC) to homogeneity is required to study their self-renewal, differentiation, phenotype, and homing. Long-term repopulation (LTR) of irradiated hosts and serial transplantation to secondary hosts represent the gold standard for demonstrating self-renewal and differentiation, the defining properties of HSC. We show that rare cells that home to bone marrow can LTR primary and secondary recipients.
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