Publications by authors named "S Netser"

Article Synopsis
  • * In a study using Cntnap2-knockout mice (a model for ASD), researchers found these mice could not distinguish emotional states in social interactions and showed abnormal brain activity patterns, characterized by higher theta and gamma rhythms.
  • * The study also revealed that enhanced communication between the prelimbic cortex and the hypothalamic paraventricular nucleus correlated with social behavior, suggesting that disruptions in these brain regions contribute to emotion recognition deficits in ASD.
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Social behavior is highly complex and adaptable. It can be divided into multiple temporal stages: detection, approach, and consummatory behavior. Each stage can be further divided into several cognitive and behavioral processes, such as perceiving social cues, evaluating the social and non-social contexts, and recognizing the internal/emotional state of others.

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Mammalian social behavior is highly context-sensitive. Yet, little is known about the mechanisms that modulate social behavior according to its context. Recent studies have revealed a network of mostly limbic brain regions which regulates social behavior.

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Article Synopsis
  • Social behaviors are essential for human connection and can be affected by conditions like Autism Spectrum Disorder (ASD), which involves disruptions in the mesoaccumbens pathway (VTA and NAc).
  • The study investigates a specific mutation linked to ASD, using a -deficient rat model to assess how this mutation alters social reward processing and behavior.
  • Findings reveal that -deficient rats show unusual social interactions and struggle with reward-based behavior due to changes in neuronal activity, but adjusting VTA neuron activity can help normalize their behavior, suggesting potential intervention pathways.
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