Publications by authors named "S Neidhart"
Background: The presence of intrathecal total IgG production is a hallmark of cerebrospinal fluid (CSF) characteristics in multiple sclerosis (MS). Herein, we systematically analyze how the intensity (instead of mere presence) of intrathecal total IgG production relates to basic CSF parameters in MS.
Methods: We retrospectively assessed clinical routine CSF findings from 390 therapy-naïve relapsing-remitting MS patients diagnosed according to 2017 revised McDonald criteria.
Background/objectives: We aimed to determine in multiple sclerosis (MS) whether intrathecal immunoglobulin G (IgG) production against measles- (M), rubella- (R), and varicella zoster (Z) viruses, which is called MRZ reaction (MRZR) and considered the most specific soluble biomarker for MS, is associated with demographic and basic cerebrospinal fluid (CSF) parameters reflecting inflammation.
Methods: We analyzed the presence of positive MRZR and associations with demographic and clinical routine CSF parameters in 513 patients with MS and 182 non-MS patients.
Results: Comparing MS patients versus non-MS patients, positive MRZR (38.
Article Synopsis
- - A 46-year-old man with Lennox-Gastaut syndrome and drug-resistant epilepsy underwent bilateral deep brain stimulation (DBS) to help manage his condition.
- - After initial DBS activation, he experienced worsened ataxia and dysarthria, which improved when the stimulation was adjusted to reduce stimulation from certain areas.
- - This case highlights that careful adjustment of DBS parameters can mitigate side effects like dysarthria while still providing effective treatment for epilepsy.
Objective: Specific human leucocyte antigen (HLA) alleles are not only associated with higher risk to develop multiple sclerosis (MS) and other autoimmune diseases, but also with the severity of various viral and bacterial infections. Here, we analyzed the most specific biomarker for MS, that is, the polyspecific intrathecal IgG antibody production against measles, rubella, and varicella zoster virus (MRZ reaction), for possible HLA associations in MS.
Methods: We assessed MRZ reaction from 184 Swiss patients with MS and clinically isolated syndrome (CIS) and 89 Swiss non-MS/non-CIS control patients, and performed HLA sequence-based typing, to check for associations of positive MRZ reaction with the most prevalent HLA alleles.
Article Synopsis
- MOGAD is a rare autoimmune disease that can resemble multiple sclerosis (MS), making diagnosis challenging due to variable antibody assay results and low-positive titers.
- The study analyzed CSF parameters from 30 MOGAD patients and 189 MS patients to identify differences that could aid in distinguishing between the two conditions.
- Results showed that MOGAD patients often had a higher white cell count and specific CSF characteristics compared to MS patients, with significant indicators like a Q ratio greater than 10×10 and the absence of CSF-restricted OCB suggesting a diagnosis of MOGAD.