Publications by authors named "S Nedunchezhian"
Recent advances in microfluidic chip technologies for applications as preclinical testing devices for the diagnosis and treatment of triple-negative breast cancers.
Pathol Res Pract
December 2024
The leading cause of cancer-related death among female patients is breast cancer. Among all the types of breast cancer, triple-negative breast cancer (TNBC) is the most dangerous molecular subtype of breast cancer characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2) expression. Since there is no particular therapeutic strategy for TNBC that has been shown to worsen the disease prognosis, 3D models are superior to 2D models as a predictive tool for drug discovery because they more accurately reflect the in vivo biological components of humans.
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- South Asian Americans face significant challenges related to atherosclerotic cardiovascular disease (ASCVD), and the study examines the sustainability of the South Asian Healthy Lifestyle Intervention (SAHELI), which is designed to improve dietary habits, physical activity, and stress management within this population.
- The research utilized a mixed-methods approach involving surveys and thematic analysis with 17 partners from various organizational settings, revealing that the program is well-received for its cultural responsiveness but faces barriers like financial support and infrastructure.
- The findings highlight that while SAHELI is effective in addressing community-specific health needs and perceptions about research, ensuring its long-term sustainability will require overcoming identified challenges in resources and leadership.
Study Objective: Non-Hispanic Black (NHB) adults have high hypertension (HTN) and cardiovascular disease (CVD) burden. Medication nonadherence limits control and self-measured blood pressure (SMBP) improves diagnosis and adherence. This predominantly NHB cohort pilot, via community-clinical linkages, with uncontrolled HTN and low adherence, utilized bidirectional electronic messaging (BEM) with team-care, to assess medication adherence, quality of life, and BP.
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