Publications by authors named "S Naveau"

Background: Polygenic Risk Scores (PRS) based on results from genome-wide association studies offer the prospect of risk stratification for many common and complex diseases. We developed a PRS for alcohol-associated cirrhosis by comparing single-nucleotide polymorphisms among patients with alcohol-associated cirrhosis (ALC) versus drinkers who did not have evidence of liver fibrosis/cirrhosis.

Methods: Using a data-driven approach, a PRS for ALC was generated using a meta-genome-wide association study of ALC (N=4305) and an independent cohort of heavy drinkers with ALC and without significant liver disease (N=3037).

View Article and Find Full Text PDF

Purpose: Obesity is an independent risk factor for renal injury. A more favorable metabolic environment following weight loss may theoretically lead to improved renal function. We aimed to evaluate the evolution of renal function one year after sleeve gastrectomy in a large prospective cohort of patients with morbid obesity and assess the influence of fat-free mass (FFM) changes.

View Article and Find Full Text PDF

Background & Aims: Only a minority of excess alcohol drinkers develop cirrhosis. We developed and evaluated risk stratification scores to identify those at highest risk.

Methods: Three cohorts (GenomALC-1: n = 1,690, GenomALC-2: n = 3,037, UK Biobank: relevant n = 6,898) with a history of heavy alcohol consumption (≥80 g/day (men), ≥50 g/day (women), for ≥10 years) were included.

View Article and Find Full Text PDF
Article Synopsis
  • The study evaluates the effectiveness of the Controlled Attenuation Parameter (CAP) as a non-invasive tool for assessing liver steatosis in obese patients, with a focus on establishing diagnostic cutoffs and performance accuracy.
  • An individual patient data meta-analysis included data from 16 studies, encompassing 2,346 patients with various liver diseases and varying body mass indices (BMIs).
  • Results showed that the majority of patients had non-alcoholic fatty liver disease (NAFLD), and the XL probe was recommended for assessing them, highlighting the need for standardized diagnostic criteria.
View Article and Find Full Text PDF