Publications by authors named "S Navani"
Background: Considering that dementia is an international public health priority, several countries have developed national dementia strategies outlining initiatives to address challenges posed by the disease. These strategies aim to improve the care, support, and resources available to meet the needs of persons living with dementia and their care partners and communities. Despite the known impact of social determinants of health on dementia risk, care, and outcomes, it is unclear whether dementia strategies adequately address related inequities.
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- Phosphorylation influences protein activity in cells, and this study examined its effects in gastric cancer, highlighting issues with kinases that lead to abnormal phosphorylation of important proteins.
- Researchers used advanced techniques to analyze protein phosphorylation in gastric cancer tissues and identified key signaling pathways, focusing on the kinase CLK1 as a significant regulator.
- Inhibition of CLK1 led to decreased cancer cell viability and movement, suggesting it could be a promising target for therapeutic strategies against gastric cancer.
Gallbladder cancer (GBC) is a rare malignancy, associated with poor disease prognosis with a 5-year survival of only 20%. This has been attributed to late presentation of the disease, lack of early diagnostic markers and limited efficacy of therapeutic interventions. Elucidation of molecular events in GBC can contribute to better management of the disease by aiding in the identification of therapeutic targets.
View Article and Find Full Text PDFBackground: There is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC).
Methods: Human Protein Atlas data resources, including the transcriptomes and proteomes of normal and malignant human tissues, were searched for RCC-specific proteins and cubilin (CUBN) identified as a candidate. Patient tissue representing various cancer types was constructed into a tissue microarray (n = 940) and immunohistochemistry used to investigate the specificity of CUBN expression in RCC as compared to other cancers.