Publications by authors named "S Nassiri"
The acute response to therapeutic afterload reduction differs between heart failure with preserved (HFpEF) versus reduced ejection fraction (HFrEF), with larger left ventricular (LV) stroke work augmentation in HFrEF compared to HFpEF. This may (partially) explain the neutral effect of HFrEF-medication in HFpEF. It is unclear whether such differences in hemodynamic response persist and/or differentially trigger reverse remodeling in case of long-term afterload reduction.
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- Plasmacytoid dendritic cells (pDCs) are important for immune responses but are rare in blood and less effective in cancer, making their use in therapies difficult.
- Researchers developed a new method to differentiate pDCs from cord blood stem cells using specific growth factors like SR-1 and GM-CSF, leading to a significant yield of functional pDCs.
- The study found that these cord blood-derived pDCs closely resemble primary pDCs and can potentially enhance anti-tumor immune responses, making them promising candidates for cancer therapies.
Article Synopsis
- * Current methods for identifying highly variable genes (HVGs) often show inconsistent performance and struggle with fine-resolution datasets and minority cell types, raising concerns about the accuracy of their results.
- * To address these issues, the authors introduce Mcadet, a new feature selection framework that combines Multiple Correspondence Analysis, graph-based community detection, and statistical testing, demonstrating its superior effectiveness in selecting HVGs through evaluations on simulated and real data.
Cost-effectiveness of hysterectomy, first- and second-generation endometrial ablation, and levonorgestrel-releasing device for treatment of heavy menstrual bleeding: a systematic review.
Expert Rev Pharmacoecon Outcomes Res
October 2024
Objectives: This study aims to provide a clear understanding of the relative economic evaluation of hysterectomy, first- and second-generation endometrial ablation, and levonorgestrel-releasing intrauterine device for treatment of heavy menstrual bleeding.
Methods: A comprehensive search was conducted without restrictions until October 5, 2023, across databases including PubMed, EMBASE, Scopus, Cochrane, and others. The review included studies using full economic evaluation methods to compare treatments, excluding review articles, editorials, abstracts, and non-English articles.
Article Synopsis
- Glioblastoma recurrence remains unavoidable even after intensive treatments, with studies showing that targeting tumor-associated macrophages can reduce tumors and improve survival.
- However, around 50% of cases in long-term studies still saw recurrences linked to fibrotic scars, which form after multiple treatments.
- Research identified these fibrotic areas as protective environments for surviving cancer cells, and blocking the associated signaling pathways improved outcomes in preclinical trials of anti-CSF-1R therapy.