Publications by authors named "S Nashimoto"
Background: Augmented renal clearance (ARC) decreases the therapeutic concentration of drugs excreted by the kidneys in critically ill patients. Several ARC prediction models have been developed and validated; however, their usefulness in Japan has not been comprehensively investigated. Thus, we developed a unique ARC prediction model for a Japanese mixed intensive care unit (ICU) population and compared it with existing models.
View Article and Find Full Text PDFClinical research for saliva-based therapeutic drug monitoring of linezolid.
Br J Clin Pharmacol
October 2024
Article Synopsis
- Linezolid is used to treat resistant infections, but its use can lead to thrombocytopenia; monitoring drug levels in plasma is helpful, though collecting samples can be inconvenient.
- A study involving patients receiving linezolid measured drug concentrations in both plasma and saliva to explore saliva as a less burdensome monitoring alternative.
- Results showed a strong correlation between linezolid levels in saliva and plasma, especially in those given intravenous doses, suggesting saliva could effectively replace plasma for monitoring in clinical settings.
Background: Patients treated with linezolid (LZD) frequently develop thrombocytopenia, and previous studies have identified the risk factors for this condition. However, the relationship between the development of LZD-induced thrombocytopenia and baseline platelet count has varied according to different reports.
Aim: To explore the relationship between platelet count and the development of LZD-induced thrombocytopenia.
Article Synopsis
- * Using mouse models treated with clodronate-liposomes to deplete macrophages, researchers found that Klebsiella pneumoniae can damage the intestinal lining and spread to the liver.
- * The findings highlight the crucial role of intestinal macrophages in preventing the translocation of commensal K. pneumoniae to the liver, suggesting that these mouse models can be useful for developing treatments to combat K. pneumoniae infections.
Platelets have been reported to exert diverse actions besides hemostasis and thrombus formation in the body. However, whether platelets affect transporter activity remains to be determined. In this study, we examined the effects of platelets on the activity of amino acid transporter system A, which is known to be changed by various factors, and we clarified the mechanism by which platelets affect system A activity.
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