Publications by authors named "S Narreddy"
Article Synopsis
- - This study aimed to investigate the relationship between SARS-CoV-2 variants and the severity of COVID-19 across India, using a nationwide platform for molecular epidemiology analysis.
- - Conducted from September 2021 to December 2022, the cohort included nearly 5,000 participants, with successful sequencing of 2,723 samples, revealing key insights about different virus variants and their impacts on health outcomes.
- - Findings demonstrated that the Delta variant significantly raised the risk of severe disease, while Omicron presented a milder illness, with age, comorbidities, and lack of vaccination identified as major risk factors for mortality.
Objective: We intend to identify differences in the clinicodemographic and laboratory findings of COVID-19 patients to predict disease severity and outcome on admission.
Methods: This single-centred retrospective study retrieved laboratory and clinical data from 350 COVID-19 patients on admission, represented as frequency tables. A multivariate regression model was used to assess the statistically significant association between the explanatory variables and COVID-19 infection outcomes, where adjusted odds ratio (AOR), value, and 95% CI were used for testing significance.
Background: Global randomised controlled trials of the anti-IL-6 receptor antibody tocilizumab in patients admitted to hospital with COVID-19 have shown conflicting results but potential decreases in time to discharge and burden on intensive care. Tocilizumab reduced progression to mechanical ventilation and death in a trial population enriched for racial and ethnic minorities. We aimed to investigate whether tocilizumab treatment could prevent COVID-19 progression in the first multicentre randomised controlled trial of tocilizumab done entirely in a lower-middle-income country.
View Article and Find Full Text PDFObjective: The aim of this study was to compare the mutual interchangeability of 4 cardiac output measuring devices by comparing their accuracy, precision, and trending ability.
Design: A single-center prospective observational study.
Design: Nonuniversity teaching hospital, single center.