Publications by authors named "S Narendran"
Objective: This study evaluated the RID-MyC (Rapid Identification of Mycoses using clustered regularly interspaced short palindromic repeats [CRISPR]) assay, a CRISPR/Cas12a-based diagnostic tool, for its efficacy in diagnosing fungal endophthalmitis (FE) compared with panfungal polymerase chain reaction (PCR) and culture methods.
Design: A comparative cross-sectional study assessing the performance of the RID-MyC assay against established diagnostic modalities for FE.
Subjects: The study included 133 intraocular samples from 117 patients with suspected microbial endophthalmitis.
Aims: This report summarizes clinical findings, diagnosis, management, and long term outcomes of a recalcitrant and keratitis.
Methods And Materials: An otherwise healthy male patient presented with a corneal infiltrate with predominantly fungal characteristics, but atypical in terms of progression. The infiltrate remained undiagnosed even after several scrapings, and aqueous tap cultures.
Inflammasome activation is implicated in diseases of aberrant angiogenesis such as age-related macular degeneration (AMD), though its precise role in choroidal neovascularization (CNV), a characteristic pathology of advanced AMD, is ill-defined. Reports on inhibition of inflammasome constituents on CNV are variable and the precise role of inflammasome in mediating pathological angiogenesis is unclear. Historically, subretinal injection of inflammasome agonists alone has been used to investigate retinal pigmented epithelium (RPE) degeneration, while the laser photocoagulation model has been used to study pathological angiogenesis in a model of CNV.
View Article and Find Full Text PDFArticle Synopsis
- The study examined the occurrence and characteristics of hemifacial spasm (HFS) in 85 patients at a South Indian eye care center, focusing on potential links to systemic diseases.
- The average age of patients was around 56 years, with a majority experiencing left-side involvement and primary HFS; MRI showed neurovascular conflicts in some cases.
- The findings suggested a significant association between HFS and hypertension, indicating that further research is needed to clarify this relationship.