Enhanced pharmacokinetic approach for anastrozole via macromolecule-based silk fibroin nanoparticles incorporated injectables for oestrogen-positive breast cancer therapy.

Breast cancer (BC) is a substantial reason for cancer-related mortality among women across the globe. Anastrozole (ANS) is an effective orally administered hormonal therapy for oestrogen-positive (ER+) BC treatment. However, several side effects and pharmacokinetic limitations restricted the uses of ANS in BC therapy.

Trainee Autonomy and Supervision in the Inpatient Clinical Learning Environment.

Background: Balancing autonomy and supervision during medical residency is important for trainee development while ensuring patient safety. In the increasingly complex inpatient clinical learning environment, tension exists when this balance is skewed. In this study, we aimed to understand current and ideal states of autonomy and supervision and then describe factors that contribute to imbalance from both trainee and attending perspectives.

Development of genomic evaluation for methane efficiency in Canadian Holsteins.

Reducing methane (CH) emissions from agriculture, among other sectors, is a key step to reducing global warming. There are many strategies to reduce CH emissions in ruminant animals, including genetic selection, which yields cumulative and permanent genetic gains over generations. A single-step genomic evaluation for methane efficiency (MEF) was officially implemented in April 2023 for the Canadian Holstein breed, aiming to reduce CH emissions without affecting production levels.