Publications by authors named "S Nakanuma"
Purpose: In the current situation of an increasing older adult population with perihilar cholangiocarcinoma (PHCC), the benefits and risks of surgical treatment of PHCC in older people remain controversial. Portal vein embolization (PVE) is a useful preoperative procedure to improve hepatic reserve in the future remnant liver (FRL) and avoid postoperative liver failure after extended hepatectomy for PHCC. This study aimed to evaluate the influence of aging on PVE.
View Article and Find Full Text PDFBackground: Although postoperative portal vein thrombosis (PVT) is a frequent complication of splenectomy, few studies have examined PVT after simultaneous hepatectomy and splenectomy (HS). The aim of this study was to clarify the risk factors for and characteristics of PVT after HS.
Methods: This retrospective observational study included 102 patients, including 76 with liver cirrhosis (LC) and 26 without, who underwent HS between April 2004 and April 2021.
Impact of aging on peribiliary glands in ischemia-reperfusion injury.
J Hepatobiliary Pancreat Sci
October 2024
Article Synopsis
- - The study investigates how aging affects the peribiliary gland's (PBG) response to ischemia-reperfusion injury (IRI) in liver tissue from young and old rats.
- - Results indicate that old rats experienced significant increases in PBG volume and cell proliferation, as well as more mucus production and oxidative stress compared to young rats following IRI.
- - Findings suggest that differences in the PBG's response to injury based on age may contribute to the frequency of ischemia-type biliary lesions (ITBLs) in aged donor grafts.
Cholangiolocarcinoma (CLC) is an extremely rare tumor classified as a subtype of small duct-type intrahepatic cholangiocarcinoma (iCCA). There are few detailed reports on CLC and the prognostic impact of tumor heterogeneity is not clear. Between April 2006 and June 2022, of the 774 primary liver cancer resection cases who presented at Kanazawa University Hospital, 14 patients were pathologically diagnosed with CLC through immunohistochemical analysis of their molecular and biological features.
View Article and Find Full Text PDFObjectives: Although the dorsal pancreatic artery (DPA) is an important artery that supplies the pancreas, its morphology has not been sufficiently studied. We investigated the morphology of the DPA and the progression of pancreatic cancer along this vessel.
Materials And Methods: Overall, 142 patients with pancreatic cancer who underwent surgical resection at Kanazawa University Hospital between 2004 and 2015 were enrolled.