Publications by authors named "S Nakai"
Psoriasis is a multifactorial disorder mediated by IL-17-producing T cells, involving immune cells and skin-constituting cells. Semaphorin 4A (Sema4A), an immune semaphorin, is known to take part in T helper type 1/17 differentiation and activation. However, Sema4A is also crucial for maintaining peripheral tissue homeostasis and its involvement in skin remains unknown.
View Article and Find Full Text PDFBackground: Osteosarcoma, the most common primary bone malignancy, has a complex genetic basis and two incidence peaks. In younger patients, the standard treatment involves wide surgical resection combined with adjuvant chemotherapy; however, the role of chemotherapy in elderly patients remains controversial. The aims of this study were to investigate genetic differences between younger and elderly patients with osteosarcoma and to identify genetic signatures associated with chemotherapy response.
View Article and Find Full Text PDFBackground: Monitoring of serum alkaline phosphatase (ALP) is recommended in the management of chronic kidney disease (CKD)-mineral bone disorder (MBD) because of associations with poor outcome among dialysis patients. However, such associations may have changed with several advances in the management of CKD-MBD over the last decade.
Methods: Baseline data for 241,670 dialysis patients (mean age, 69 ± 12 years; male, 65.
Article Synopsis
- Uncomplicated Stanford type B aortic dissection (TBAD) can lead to serious aorta-related complications, but predicting which patients are at risk is challenging.
- This study analyzed patient data from two hospitals in Japan to find imaging parameters that could forecast these complications, focusing on computed tomography (CT) results.
- The findings revealed that a low true lumen area ratio (TLAR) at the subacute phase is a strong predictor of complications, even if the aortic diameter is normal, indicating that patients with this condition might need more vigilant treatment strategies.
Objective: Preemptive thoracic endovascular aortic repair (TEVAR) has the potential to improve the prognosis of Stanford type B aortic dissection (TBAD), however it is important to determine whether it could be safely performed as a prophylactic treatment. This study aimed to determine the short- and long-term outcomes of preemptive TEVAR for uncomplicated TBAD with a small aortic aneurysm.
Design: Retrospective multicenter analysis.