Publications by authors named "S Nagueh"
Purpose To investigate the determinants and effect of right ventricular (RV) dysfunction in aortic regurgitation (AR) using cardiac MRI. Materials and Methods This study included patients with moderate or severe AR who were enrolled in the DEBAKEY-CMR registry between January 2009 and June 2020. Patients with previous valve intervention, cardiomyopathy deemed unrelated to AR, severe aortic stenosis, and other confounders were excluded.
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- The study explored the impact of residual transmitral mean pressure gradient (TMPG) after mitral transcatheter edge-to-edge repair (M-TEER) on patient outcomes, focusing on all-cause mortality and hospitalizations related to heart failure.
- Higher baseline TMPG was found to predict increased residual TMPG post-procedure, with patients in the highest quartile experiencing significantly worse outcomes, including higher risks of mortality and heart failure hospitalization over three years.
- The findings suggest that efforts should be made to minimize residual TMPG after M-TEER, particularly in patients with primary mitral regurgitation (MR).
Background: Standard-of-care (SoC) medications for the treatment of obstructive hypertrophic cardiomyopathy (oHCM) are recommended as first-line therapy despite the lack of evidence from controlled clinical trials and well known off-target side effects.
Objectives: We describe the impact of SoC therapy downtitration and withdrawal in patients already receiving aficamten in FOREST-HCM (Follow-Up, Open-Label, Research Evaluation of Sustained Treatment with Aficamten in Hypertrophic Cardiomyopathy; NCT04848506).
Methods: Patients receiving SoC therapy (beta-blocker, nondihydropyridine calcium-channel blocker, and/or disopyramide) were eligible for protocol-guided SoC downtitration and withdrawal at the discretion of the investigator and after achieving a stable dose of aficamten for ≥4 weeks.
Article Synopsis
- PDS (post-pericardiotomy syndrome) can occur as a complication of pericardiocentesis.
- Caution is advised when performing pericardiocentesis on effusions where the duration is unknown.
- Using bedside transthoracic echocardiography (TTE) for regular assessments can help manage a careful and slow pericardiocentesis to reduce the risk of PDS.
Article Synopsis
- The study investigates the significance of measuring pulmonary venous flow (PVF) patterns during mitral transcatheter edge-to-edge repair (TEER) to predict patient outcomes, focusing on systolic dominant-PVF (SD-PVF) morphology.
- Researchers analyzed data from 187 patients and found that those with SD-PVF had lower rates of severe residual mitral regurgitation (MR) and were less likely to experience all-cause mortality or heart failure hospitalization within one year.
- The findings suggest that post-TEER PVF morphology could serve as an effective and straightforward prognostic tool, but more large-scale studies are needed to validate its impact further.