Publications by authors named "S Nagendra Boopathy"
Introduction: Diabetes mellitus is a global health burden, and India is regarded as the diabetes capital of the world. Glycaemic variability (GV) is an established risk factor for hypoglycaemia (plasma glucose concentration <70 mg/dL) and a notorious risk factor for diabetes complications. The primary aim of the study was to assess the correlation between the GV indices, HbA1c levels, and measures of hypoglycaemia in patients with type 2 DM (T2DM).
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- Mitochondrial fusion involves the merging of four bilayers into two, which is influenced by the outer-membrane protein SLC25A46 interacting with dynamin family GTPases Mfn1/2 and Opa1.
- Researchers employed crosslinking mass spectrometry and AlphaFold 2 modeling to discover how SLC25A46 interacts specifically with Opa1 and Mfn2.
- The study identifies key interaction interfaces that are crucial for maintaining mitochondrial structure and function.
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- Microglia, immune cells in the brain, are key players in neurodegenerative diseases, but the exact reasons for their dysfunction are still not fully understood.
- This study focuses on microglia-like cells derived from human stem cells with mutations in the PFN1 gene linked to ALS, revealing significant metabolic and functional impairments, such as lipid dysregulation and poor phagocytosis.
- The research suggests that the mutated PFN1 gene may lead to toxic effects in important cellular processes, but treatment with rapamycin can improve the disturbed functions in these cells, highlighting their potential in studying neurodegenerative diseases.
Mitochondrial fusion requires the sequential merger of four bilayers to two. The outer-membrane solute carrier protein SLC25A46 interacts with both the outer and inner-membrane dynamin family GTPases Mfn1/2 and Opa1. While SLC25A46 levels are known to affect mitochondrial morphology, how SLC25A46 interacts with Mfn1/2 and Opa1 to regulate membrane fusion is not understood.
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