Publications by authors named "S Nadesapillai"
Article Synopsis
- - The study aimed to investigate how removing one ovary for ovarian tissue cryopreservation (OTC) affects the remaining ovary's function in girls with Turner syndrome, monitoring them over several years to track pubertal development and hormone levels.
- - Conducted at a university hospital in the Netherlands, the research involved 28 girls aged 5-19, each with different karyotypes associated with Turner syndrome, and analyzed their hormone levels and pubertal milestones post-OTC.
- - Results showed a mixed response; while many participants experienced normal pubertal developments like thelarche and menarche, a notable decline in anti-Müllerian hormone (AMH) levels occurred shortly after OTC, leading to some girls requiring hormone replacement
Background: Girls with Turner syndrome (TS) lack a partial or complete sex chromosome, which causes an accelerated decline of their ovarian reserve. Girls have to deal with several dilemmas related to their fertility, while only a limited number of them are referred to a fertility specialist and counselled about options of family planning on time.
Objective And Rationale: This scoping review provides an update of the literature on fertility in girls with TS throughout their lifespan and aims to propose a clinical practice guideline on fertility in TS.
Article Synopsis
- Turner syndrome (TS) leads to premature ovarian insufficiency, but oocyte vitrification is a viable method for preserving fertility.
- A study analyzed data from 33 women with TS who underwent vitrification between 2010 and 2021, finding a median of 20 vitrified oocytes per woman and a 4% complication rate.
- Successful pregnancies occurred in 10 women post-vitrification, but none have yet returned to use their stored oocytes, indicating the need for more research on the utilization of vitrified oocytes in TS patients.
Objective: To evaluate which girls with Turner syndrome (TS) could benefit from fertility preservation by ovarian tissue cryopreservation on the basis of karyotype, puberty status, and hormonal data.
Design: Prospective intervention study; participants were included between 2018 and 2020.
Setting: Tertiary hospital in the Netherlands.
Millions of people worldwide deal with issues concerning fertility. Reduced fertility, or even infertility, may be due to many different causes, including genetic disorders, of which chromosomal abnormalities are the most common. Fluorescence in situ hybridization (FISH) is a well-known and frequently used method to detect chromosomal aberrations in humans.
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