Publications by authors named "S Nabil"
Article Synopsis
- PARP inhibitors like Olaparib are important in treating cancers linked to BRCA mutations, but they can cause significant side effects, particularly hematologic toxicities such as anemia.
- A study in the UAE reviewed medical charts of 66 patients on Olaparib, finding that 70.8% developed anemia and about one-third experienced neutropenia and thrombocytopenia, with nearly half requiring blood transfusions.
- The research underscores the need for awareness of these adverse effects and suggests further studies to improve management strategies for patients on Olaparib to reduce hematologic complications.
Objective: Medication-related osteonecrosis of the jaw bones (MRONJ) is a well-known complication of antiresorptive and antiangiogenic drugs. Since the first report, more occurrences of MRONJ have been described worldwide. Dental extraction has been described by many studies as one of the risk factors for MRONJ.
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- The study analyzed the fatigue performance of a specific titanium alloy (Ti-6Al-4V) made using laser powder bed fusion, focusing on how defects like keyhole porosity and surface roughness affect its durability.
- Researchers used four-point bending tests and examined various surface roughness levels, discovering that fatigue life varied by 10 cycles depending on these factors.
- The findings included S-N (stress-number of cycles to failure) curves which fitted Basquin's stress-life relation for most defects, indicating that keyhole porosity had less impact on fatigue performance compared to other factors in the alloy's manufacturing process.
We showed to the same observers both dynamic and static 2D patterns that can both evoke distinctive perceptions of motion or optic flow, as if moving in a tunnel or into a dark hole. At all times pupil diameters were monitored with an infrared eye tracker. We found a converging set of results indicating stronger pupil dilations to expansive growth of shapes or optic flows evoking a forward motion into a dark tunnel.
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