Publications by authors named "S N Zhdanova"

Background: The Mekong River is the 10 largest river in the world. It is recognised as the most productive river in Southeast Asia and economically essential to the region, with an estimated 60-65 million people living in the lower Mekong Basin. The Mekong Delta within Vietnam is considered a highly vulnerable ecosystem under threat from increasing anthropogenic pressure, such as dam construction and, as a consequence, the Delta is sinking and altering the natural hydrological cycle.

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This study aimed to determine phenotypic and genotypic drug resistance patterns of strains from children with tuberculosis (TB) in China and Russia, two high-burden countries for multi/extensively-drug resistant (MDR/XDR) TB. Whole-genome sequencing data of isolates from China ( = 137) and Russia ( = 60) were analyzed for phylogenetic markers and drug-resistance mutations, followed by comparison with phenotypic susceptibility data. The Beijing genotype was detected in 126 Chinese and 50 Russian isolates.

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Article Synopsis
  • The study focuses on the Mycobacterium tuberculosis Beijing 14717-15-cluster, which is a multidrug-resistant and hypervirulent strain found mainly in the Far Eastern region of Russia.
  • Researchers collected and analyzed M. tuberculosis DNA from worldwide locations between 1996 and 2020, developing a PCR assay to identify specific mutations related to this deadly strain.
  • Phylogenomic analysis confirmed the strain's prevalence in Asian Russia and highlighted unique mutations that could enhance its pathogenicity, suggesting the need for further research on these mutations' biological effects.
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Pyrazinamide plays an important role in the treatment of tuberculosis. However, the microbiological test for pyrazinamide resistance is more complex and less reliable than testing of susceptibility to other anti-tuberculosis drugs due to the need to grow the pathogen at pH 5.5.

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The magnetic environment may influence the functioning of the cardiovascular system. It was reported that low-frequency and static magnetic fields affect hemodynamics, heart rate, and heart rate variability in animals and humans. Moreover, recent data suggest that magnetic fields affect the circadian rhythms of physiological processes.

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