Three Dimensional Printing and Finishing of In-office Provisional Full-Arch Restorations.

In recent years, the field of oral and maxillofacial surgery has witnessed a remarkable transformation resulting from advances in additive manufacturing. Better known as "3 dimensional (3D) printing," this technology offers unprecedented precision and customization in implant treatment procedures. This technology has allowed providers to efficiently fabricate highly accurate dental models, surgical guides, and prosthetic components.

Understanding oncologic emergencies and related emergency department visits and hospitalizations: a systematic review.

Background: Patients with cancer frequently visit the emergency department (ED) and are at high risk for hospitalization due to severe illness from cancer progression or treatment side effects. With an aging population and rising cancer incidence rates worldwide, it is crucial to understand how EDs and other acute care venues manage oncologic emergencies. Insights from other nations and health systems may inform resources necessary for optimal ED management and novel care delivery pathways.

Trajectories of lipid profile with cognitive function: 12-year follow-up of Guangzhou Biobank cohort study.

Studies on the trajectories of lipid profile with cognitive decline are scarce and inconsistent. We examined this association and explored potential effect modification. Lipid profiles including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and total cholesterol (TC) were measured at baseline, first and second follow-ups, and classified into trajectory groups.

Introduction to Mendelian randomization.

Mendelian randomization (MR), i.e. instrumental variable analysis using genetic instruments, is an approach that incorporates population genetics to improve causal inference.

An acidic residue within the OCT4 dimerization interface of SOX17 is necessary and sufficient to overcome its pluripotency-inducing activity.

SOX17 directs the differentiation toward endoderm and acts as a human germline specifier. We previously found that the replacement of glutamate at position 57 of the high-mobility group (HMG) box with the basic lysine residue in SOX2 alters interactions with OCT4 and turns SOX17 into a pluripotency factor. Here, we systematically interrogated how mutations at this critical position affect the cellular reprogramming activity of SOX17 in mouse and human.