[The influence of dorsal hippocampal lesion upon formation of fixated set in albino rats].

The experiments have been carried out on intact and hippocampectomized white rats. In the first stage of these experiment a two-entrance communicating chamber behind which a feeding trough was placed the animals were conditioned to food- processing reaction to visual discrimination. The two doors of this chamber were illuminated with different intensity.

Investigation of binding process of chlorpromazine to bovine serum albumin by means of passive and active experiments.

The association process of chlorpromazine with bovine serum albumin by both onefactoral passive and multifactoral active experiments were investigated in model systems. The dependence of absolute concentration of the free fraction of chlorpromazine on the total concentration of chlorpromazine is described by the increasing function, but the dependence of the relative concentration (free/total) on this factor is influenced by external characteristics. The concentrations of chlorpromazine, bovine serum albumin and Tritons' mixture, as principal factors of a multifactoral experiment, influence the absolute and relative values of the free fraction of chlorpromazine non-additively, ie the interaction of factors is significant.

Cloud-point extraction for the determination of the free fraction of antiepileptic drugs in blood plasma and saliva.

A method for the determination of the free fraction of antiepileptic drugs in plasma and saliva was developed. The separation of free and protein-bound fractions was obtained by cloud-point extraction under optimum conditions of pH, surfactant type, and concentration. It is shown that the free fraction of carbamazepine and of phenobarbital in plasma coincides with the drug concentration in saliva.

Interaction of carbamazepine and phenobarbital in rabbits.

The interaction of carbamazepine and phenobarbital in rabbits was investigated. The drugs were administered to the rabbit orally as a single dose. By simultaneous administration the sequence of drugs was varied, with an interval between doses of 15 min.

Interaction of carbamazepine and chlorpromazine in rabbits.

The interaction of carbamazepine and chlorpromazine in rabbits has been studied. The drugs were administrated as single oral doses (200 mg of each drug). The sequence of administration of the drugs was varied.