High- and Moderate-Risk Variants Among Breast Cancer Patients and Healthy Donors Enrolled in Multigene Panel Testing in a Population of Central Russia.

Assessments of breast cancer (BC) risk in carriers of pathogenic variants identified by gene panel testing in different populations are highly in demand worldwide. We performed target sequencing of 78 genes involved in DNA repair in 860 females with BC and 520 age- and family history-matched controls from Central Russia. Among BC patients, 562/860 (65.

CD38 gene polymorphism rs1130169 contribution to the increased gene expression and risk of colorectal cancer (pilot study).

Background: Genetic variations in immune signaling genes may have regulatory effect on phenotypic heterogeneity of immune cells and immune functions, hence promoting tumor growth.

Purpose: We compared the frequencies of potentially functional CD38 gene single nucleotide polymorphisms rs1130169 (T > C) in 86 healthy controls and 90 colorectal cancer (CRC) cases to assess their association with cancer risk and CD38 gene expression.

Results: The association between allele C rs1130169 and CRC risk was observed.

[Structural changes in human brain tissue during prenatal alcoholization at different stages of intrauterine development].

Objective: To assess the degree of influence of intrauterine alcoholization on the formation of various structural components of the brain of human embryos.

Material And Methods: Twenty-six samples of embryonic material from 8 to 11 weeks of intrauterine development were studied. The material was divided into four subgroups in accordance with the gestational age (Control 1 - 8-9 weeks of gestation and Control 2 - 10-11 weeks of gestation) and the history of the mother (presence or absence of the diagnosis «Alcoholism stage I-II» in the anamnesis).

Photosystem II in bio-photovoltaic devices.

Hybrid photoelectrodes containing biological pigment-protein complexes can be used for environmentally friendly solar energy conversion, herbicide detection, and other applications. The total number of scientific publications on hybrid bio-based devices has grown rapidly over the past decades. Particular attention is paid to the integration of the complexes of PSII into photoelectrochemical devices.

[The correlation of expression of MUC1, ICAM1, IL32, FcyR3A and FoxP3 in tumor niduses of patients with breast cancer].

The hypo-glycated mucin I (MUC I) frequently is redundantly expressed in cells of breast carcinoma that is considered as an unfavorable prognostic marker for patients with breast cancer. The purpose of study is to evaluate in tumor areas of patients with breast cancer the interrelationships between expression of MUC I and genes participating in implementation of immune reactions. The technique of polymerase chain reaction with reverse transcription in real-time was applied to investigate expression of genes of MUC I, Fas, ICAMI, FcyR3A, FcyR3B, FoxP3, IL2Ra, IL32 and TNF in tumor areas of 40 patients with breast cancer.