[A case of prolonged remission after discontinuation of biological therapy in a patient with severe uncontrolled chronic rhinosinusitis with nasal polyps].

Currently, targeted biological therapy is an innovative and highly effective approach in the treatment of severe chronic rhinosinusitis with nasal polyps (CRSwNP) associated with T2 inflammation that is uncontrolled by standard treatment methods. The article presents the first experience of long-term observation of a patient who, one year after the start of targeted biological therapy with dupilumab, independently stopped the treatment due to complete relief of symptoms of CRSwNP, despite recommendations to continue therapy to maintain control. At the same time, one year after the refusal of biological therapy, the patient showed persistent clinical remission in relation to the symptoms of CRSwNP, confirmed by the results of videoendoscopic examination of the nasal cavity and computed tomography of the sinuses.

[The possibilities of a dosage form with the active substance acylsarcosinate and sucrose laurate, in the implementation of the issue of cerumenolysis. Literature review].

The observed increase in cases of earwax plugs in patients, as well as the variety of methods of their removal using agents with different cerumenolysis activity, emphasize the need to search for the most modern and multifunctional otolaryngological preparations with proven efficacy. Based on the results of the analysis and generalization of literature sources on the treatment and prevention of ear sulfur plugs, presented in specialized publications in the Russian scientific eLibrary and scientific databases MedLine, Web of Science, Scopus, the need to optimize treatment methods and preventive measures has been identified. In this regard, it is recommended to widely use the preparation A-Cerumen Plus as one of the most progressive means.

Laser-Driven Proton-Only Acceleration in a Multicomponent Near-Critical-Density Plasma.

An experimental investigation of collisionless shock ion acceleration is presented using a multicomponent plasma and a high-intensity picosecond duration laser pulse. Protons are the only accelerated ions when a near-critical-density plasma is driven by a laser with a modest normalized vector potential. The results of particle-in-cell simulations imply that collisionless shock may accelerate protons alone selectively, which can be an important tool for understanding the physics of inaccessible collisionless shocks in space and astrophysical plasma.