Publications by authors named "S N Rizk"
In this study, a nanocomposite based on copper oxide-zinc oxide nanoparticles and Gum Arabic (GA@CuO-ZnO nanocomposite) was successfully synthesized using green method. Characterization results revealed that the prepared nanocomposite appeared at the nanoscale level, showed excellent dispersion, and formed stable colloidal nano-solutions. The bimetallic GA@CuO-ZnO nanocomposite was evaluated for its anticancer, antibacterial, and antifungal properties.
View Article and Find Full Text PDFColorectal cancer (CRC) is the third most prevalent cancer worldwide. While chemotherapy remains the standard treatment approach, natural products have emerged as a promising alternative. Among these, apigenin, a natural flavonoid, has garnered significant attention due to its pro-oxidant and antioxidant properties in various types of cancer.
View Article and Find Full Text PDFInnovative super-hydrophilic/superoleophobic eco-friendly sponge composite is fabricated by integrating chemically-modified cellulose with lignin derived from bio-waste wheat-straw. Such combination is implemented by modifying cellulose with thiadiazole-amide and integrating it with lignin using microwave/ultrasonic-powered in-liquid plasma. Physicochemical characteristics of sponge-composite (WL-TDAC) are studied using FTIR, N-physisorption, DLS, SEM, chemical-computational analysis, and surface wettability.
View Article and Find Full Text PDFBackground: Pediatric patients infected with coronavirus disease 2019 (COVID-19) have unique clinical characteristics. Tumor necrosis factor (TNF) is a proinflammatory cytokine that greatly contributes to tumor pathogenesis.
Purpose: To describe the presenting characteristics of COVID-19 infection among pediatric patients, and investigate the possible role of the TNF-α signaling pathway.
Article Synopsis
- - Niemann-Pick type C disease is caused mainly by mutations in the NPC1 gene, leading to cholesterol buildup and lysosomal dysfunction.
- - The study tested polyphenol-rich extracts from *L.* (RCME) and its components, rutin and quercitrin, to see if they could improve NPC1 protein trafficking and reduce cholesterol levels in NPC patient-derived fibroblasts, finding that RCME was effective while the drug miglustat was not.
- - RCME was shown to improve the trafficking of various NPC1 mutants and lower cholesterol levels, suggesting it may be a more effective therapeutic option than current treatments that only reduce cholesterol levels.