Publications by authors named "S N Proshin"
Recently, due to the emergence of a variety of modifications of air, land, water vehicles and an increase in their speed and maneuverability, the number of people with severe manifestations of motion sickness has also increased. The relevance of this problem is dictated by the fact that, despite significant achievements in the field of preventive medicine, a significant number of people prone to motion sickness have been observed to date. Thus, among persons using land modes of transport, the percentage of sick people reaches 15.
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- Recent studies have established a clear link between the structural design of drug compounds and their biological effectiveness, highlighting the importance of stereoisomers in both therapeutic outcomes and potential side effects.
- The use of computational methods, particularly Quantitative Structure-Activity Relationships (QSAR) alongside molecular modeling, has become essential in modern drug discovery, allowing for computer-based drug searches before moving to lab experiments.
- With over 101 million known organic compounds and more than 25,000 recognized biological activities, in silico methods are increasingly vital for efficiently screening and identifying promising drug candidates.
Kisspeptin is the peptide product of the KiSS-1 gene and endogenous agonist for the Kiss1 receptor. It is known that kisspeptin, acting centrally, stimulates secretion of gonadoliberin (GnRH). Kisspeptin interacts with other neuropeptides such as neurokinin B and dynorphin, to regulate GnRH pulse generation and also plays a role in sexual behaviour.
View Article and Find Full Text PDFAim: To assess the morphological and functional characteristics of spermatozoa and DNA stability in patients with normal seed parameters and with an ITZ exceeding the threshold value.
Patients And Methods: 85 males were studied for semen quality parameters. The morphological anomalies of head, middle piece, and tail of spermatozoa were estimated and presented in illustrations.
According to the experimental data a triterpene alcohol betulin have anti-inflammatory, wound- and burn-healing activity. Previous data reports, that betulin was used in not less than 5% concentrations. That is why studying less concentrations is of major interest.
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