[Changes in activity of transcription factors in the cells of vascular endothelium as a pathological mechanism of its dysfunction in essential hypertension].

Aim: To study activity of transcription factor (TF)--the nuclear factor kappa B (NF-kB)--and its role in formation of endothelial dysfunction (ED) in patients with essential hypertension (EH).

Material And Methods: The examination covered 74 patients with EH stage I-II with the first-third degree of arterial hypertension (AH) by WHO/IHS classification (48 males, 36 females, mean age 46.39 +/- 3.

[Geometric state of the heart left ventricle and its correlation with contraction processes in patients with chronic obstructive bronchitis].

Geometrical features of contraction of the left ventricle of the heart (LVH) in 41 patients with chronic obstructive bronchitis marked by moderate and severe respiratory disorders without clinical signs of heart insufficiency with the help of a morphobiomechanical have been examined. The patients were selected in subgroups with different ejection fraction of LVH. The patients with diminished ejection fraction were found to have signs which respond to left ventricle dysfunctions of the heart.

[Remodeling of elastic arteries in patients with hypertensive disease: diagnostic value of pulse pressure].

The study was undertaken to examine a role of pulse blood pressure (PBP) as a diagnostic marker of remodeling of large elastic arteries in patients with hypertensive disease (HD). A hundred and sixty-eight patients with HD and 38 apparently healthy individuals (a control group) were examined. In all the examinees, PBP was measured and central PBP (PBPc) was calculated.

[Structural and functional reconfiguration of large arteries in hypertensive disease: a role of connective tissue metabolic disturbances].

The study was undertaken to define a role of connective tissue metabolism (CTM) in the structural and functional changes of arterial vessels in patients with hypertensive disease (HD). Eighty-nine patients with HD and 33 apparently healthy individuals were examined. The morphometrical parameters of the aorta were studied by magnetic resonance imaging (MRI), external and internal diameters (ED and ID, respectively) and the thickness of the wall (Hao) at the level of the ascending aorta and its mass (Mao) were determined.

[Assessment of quality of life in patients with chronic obstructive bronchitis].

The investigation performed in 117 patients with chronic obstructive bronchitis (COB) revealed a significant decline in quality of life (QL) with progressive disease. Decrement of QL level in patients with stage I and II COB has been found to be primarily associated with activation of the sympathetic nervous system and progressing of metabolic myocardial dystrophy. With stage III COB decline in QL is also caused by reduction of volume of the functional pulmonary parenchyma.