1,2-Dimethylhydrazine carcinogenesis in C3HA and CBA female mice prenatally treated with diethylstilbestrol.

C3HA and CBA female mice received a single intraperitoneal (i.p.) injection of 0.

[The effect of prenatal diethylstilbestrol treatment on 1,2-dimethylhydrazine-induced carcinogenesis in C3HA female mice].

C3HA female mice received 0.1-0.3 mg/g body weight diethylstilbestrol (DES) on day 17 of gestation.

[Enzymes metabolizing xenobiotics in spontaneous tumors in mice].

The microsomal monooxygenase activity in spontaneous mouse hepatomas has been studied. The cytochrome P-450 level in hepatomas was shown to be 2 times as low as that in the liver. The reduction of the cytochrome P-450 content in the tumour was accompanied by a decrease in the activity of benz(a)pyrene hydroxylase, amino-pyrene-N-demethylase and p-nitroanisole-O-demethylase.

[Early stages of hepatic carcinogenesis after vagotomy].

Initial stages of hepatocarcinogenesis have been studied in nonoperated and vagotomized animals. As a carcinogenic substance diethylnitrosamine (DENA) has been used. In order to estimate manifestation of the changes, the histochemical method for revealing glucoso-6-phosphatase activity, adenosine triphosphatase and gamma-glutamyltranspeptidase in the liver has been applied.

[Effect of the duration of administration of 1,2-dimethylhydrazine on its carcinogenic effect].

The (CBA x C57Bl)F1 female mice were treated with weekly injections of 1,2-dimethylhydrazine (DMH) at a dose rate of 4.15 mg/kg of body weight during different time periods. Relations between the incidence of organ specified particular tumours depend on the total DMH dose.