Valorization of Agricultural Residues to Valuable Products: A Circular Bioeconomy Approach.

Intensive agricultural production generates a lot of residues yearly, exhausting and depleting the soils and accumulating pesticides and mineral fertilizers. Although introducing the no-till technologies is related to the reduction of tillage, leaving most of the plant residues on the field and decreasing fertigation, the global crop residues are estimated to be 2800 million tons per year. They could be successfully utilized via several approaches integrated into the circular bioeconomy concept.

Heterodimeric vipoxin and its individual monomeric subunits display a dynamic structure-function relationship on RPE cells.

Known as some of the most toxic venom components, snake venom Phospholipases A (svPLA) impress with their great arsenal of activities, based on catalytic specificity and a variety of non-catalytic "pharmacological" effects using complex molecular mechanisms that can affect different tissues and organs. Here, we aim to reveal the role of the intricate interactions between the monomeric subunits of the heterodimeric neurotoxic complex vipoxin in order to perform multiple differentiated and regulated biological activities in RPE cells. Vipoxin, isolated from the venom of Vipera ammodytes ssp.

Acid-Base Equilibrium of 5,5,6-Trihydroxy-6-Methyldihydropyrimidine-2,4(1,3)-Dione in the Gas Phase and in Water.

The first-stage acid-base equilibrium of 5,5,6-trihydroxy-6-methyldihydropyrimidine-2,4(1,3)-dione was studied for the first time in aqueous solutions. Its constant (pK = 9.23 ± 0.

Discovery of Potent Dengue Virus NS2B-NS3 Protease Inhibitors Among Glycyrrhizic Acid Conjugates with Amino Acids and Dipeptides Esters.

This study investigated a library of known and novel glycyrrhizic acid (GL) conjugates with amino acids and dipeptide esters, as inhibitors of the DENV NS2B-NS3 protease. We utilized docking algorithms to evaluate the interactions of these GL derivatives with key residues (His51, Asp75, Ser135, and Gly153) within 10 Å of the DENV-2 NS2B-NS3 protease binding pocket (PDB ID: 2FOM). It was found that compounds and exhibited unique binding patterns, forming hydrogen bonds with Asp75, Tyr150, and Gly153.

Effect of Herbicide-Resistant Oil-Degrading Bacteria on Plants in Soil Contaminated with Oil and Herbicides.

Biological remediation of agricultural soils contaminated with oil is complicated by the presence of residual amounts of chemical plant protection products, in particular, herbicides, which, like oil, negatively affect the soil microbiome and plants. In this work, we studied five strains of bacteria of the genera and , which exhibited a high degree of oil biodegradation (72-96%). All strains showed resistance to herbicides based on 2,4-D, imazethapyr and tribenuron-methyl, the ability to fix nitrogen, phosphate mobilization, and production of indole-3-acetic acid.