Publications by authors named "S N Olof"
The bacterium causes life-threatening disease worldwide, typically with a clinical presentation of sepsis or meningitis, but can be carried asymptomatically as part of the normal human oropharyngeal microbiota. The aim of this study was to examine carriage with regard to prevalence, risk factors for carriage, distribution of meningococcal lineages and persistence of meningococcal carriage. Throat samples and data from a self-reported questionnaire were obtained from 2744 university students (median age: 23 years) at a university in Sweden on four occasions during a 12-month period.
View Article and Find Full Text PDFAdipose models have been applied to mechanistic studies of metabolic diseases (such as diabetes) and the subsequent discovery of new therapeutics. However, typical models are either insufficiently complex (2D cell cultures) or expensive and labor intensive (mice/in vivo). To bridge the gap between these models and in order to better inform pre-clinical studies we have developed a drug-responsive 3D model of white adipose tissue (WAT).
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- Bioprinting is a technique for creating living tissues by arranging cells in specific 3D shapes, but there are few high-resolution examples with multiple cell types.
- This research introduces a cost-effective method using 3D printed aqueous droplets with mammalian cells, successfully creating robust and detailed constructs in oil that can be transferred to culture medium.
- The study confirmed that cells maintained high viability and could proliferate, with a five-week experiment showing that printed stem cells could differentiate into cartilage-like structures, producing type II collagen.
We have created a 4 × 4 droplet bilayer array comprising light-activatable aqueous droplet bio-pixels. Aqueous droplets containing bacteriorhodopsin (bR), a light-driven proton pump, were arranged on a common hydrogel surface in lipid-containing oil. A separate lipid bilayer formed at the interface between each droplet and the hydrogel; each bilayer then incorporated bR.
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- Researchers have used 3D printing to create tissue-like materials made of tiny aqueous compartments separated by lipid bilayers.
- A light-activated DNA promoter allows for the expression of specific genes in synthetic cells, enabling control over protein production.
- This process leads to the development of a functional model for neuronal transmission, facilitating controlled electrical communication between different groups of cells.