Association of rs2294008 and rs9297976 Polymorphisms in PSCA Gene with Gastric Cancer Susceptibility in Uzbekistan.

Introduction: Genetic factors play an important role in the development of gastric cancer (GC), a prevalent malignancy in Central Asia. Recent studies have shown that single-nucleotide polymorphisms (SNPs) in several genes are associated with increased GC risk, indicating that genetic variation contributes to gastric carcinogenesis. Located on chromosome 8q24.

[Possibilities of study of the main cytokines of the immune system in patients with osteogenic sarcoma].

The aim of the study was to investigate the spontaneous production of the major cytokines of the immune system in patients with osteogenic sarcoma. There were studied serum concentrations of pro-inflammatory and anti-inflammatory cytokines (IL-1beta, TNF-alpha, IL-2, IL-6 and IL-10) as well as the presence of vascular endothelial growth factor (VEGF). It was revealed a misbalance in the presence of the main cytokines of the immune system in patients with osteosarcoma appeared by a significant increase in both pro-and anti-inflammatory cytokines.

[Analysis of prognostic factors influencing metastatic potential in breast cancer].

The paper discusses our data on evaluation of prognostic factors influencing metastatic potential of breast cancer and correlations which determine likelihood of tumor spreading to the lungs. Only the most plausible correlation coefficients (Chandelle) (p < or = 0.001) were used (0.