Anti-Idiotypic Antibody as a Booster Vaccine Against Respiratory Syncytial Virus.

The respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections in children and adults. With nearly everyone infected by the age of five, there is an opportunity to develop booster vaccines that enhance B-cell immunity, promoting potent and broadly neutralizing antibodies. One potential approach involves using anti-idiotypic antibodies (anti-IDs) to mimic specific antigenic sites and enhance preexisting immunity in an epitope-specific manner.

Late-Onset Sepsis Among Extremely Preterm Infants During the COVID-19 Pandemic.

Objectives: To compare incidence of late-onset sepsis (LOS) among extremely preterm infants before and during the COVID-19 pandemic.

Methods: Multicenter cohort study of infants with birthweight 401 to 1000 g or gestational age 22 to 28 weeks. LOS was defined as a bacterial or fungal pathogen isolated from blood or cerebrospinal fluid culture obtained after 72 hours of age.

Hot carrier dynamics in the BAPbBr/MoS heterostructure.

Herein, we investigated the carrier-phonon relaxation process in a two-dimensional (2D) BAPbBr perovskite and its heterostructure with MoS. Energy transfer was observed in the van der Waals heterostructure of 2D perovskite and monolayer MoS, leading to enhancement in the photoluminescence intensity of MoS. Femtosecond pump-probe spectroscopy was used to study the carrier and lattice dynamics of pristine 2D materials and their heterostructure.

Towards molecular structure discovery from cryo-ET density volumes via modelling auxiliary semantic prototypes.

Cryo-electron tomography (cryo-ET) is confronted with the intricate task of unveiling novel structures. General class discovery (GCD) seeks to identify new classes by learning a model that can pseudo-label unannotated (novel) instances solely using supervision from labeled (base) classes. While 2D GCD for image data has made strides, its 3D counterpart remains unexplored.

Chaperone-Mediated Heterotypic Phase Separation Prevents the Amyloid Formation of the Pathological Y145Stop Prion Protein Variant.

Biomolecular condensates formed via phase separation of proteins and nucleic acids are crucial for the spatiotemporal regulation of a diverse array of essential cellular functions and the maintenance of cellular homeostasis. However, aberrant liquid-to-solid phase transitions of such condensates are associated with several fatal human diseases. Such dynamic membraneless compartments can contain a range of molecular chaperones that can regulate the phase behavior of proteins involved in the formation of these biological condensates.