Interspecific differences in the response of autotrophic microorganisms to atrazine and S-metolachlor exposure.

Atrazine and S-metolachlor are herbicides widely used on corn and soybean crops where they are sometimes found in concentrations of concern in nearby aquatic ecosystems, potentially affecting autotrophic organisms. The aim of this study was to investigate the response of the green algae Enallax costatus, the diatom Gomphonema parvulum and a culture of the cyanobacteria Phormidium sp. and Microcystis aeruginosa, to atrazine and S-metolachlor alone and in mixture (0, 10, 100 and 1000 µg.

Fracture Risk Assessment in the 2023 Osteoporosis Canada Guideline.

Radiologists and other diagnostic imaging specialists play a pivotal role in the management of osteoporosis, a highly prevalent condition of reduced bone strength and increased fracture risk. Bone mineral density (BMD) measurement with dual-energy X-ray absorptiometry (DXA) is a critical component of identifying individuals at high risk for fracture. Strategies to prevent fractures are consolidated in the Osteoporosis Canada clinical practice guideline which was updated in 2023.

Anti-BCMA and GPRC5D bispecific antibodies in relapsed/refractory primary plasma cell leukemia: a case report.

Plasma cell leukemia (PCL) is an aggressive and high-risk variant of multiple myeloma (MM) with a very poor prognosis. Given its rarity and aggressiveness, there is a lack of clinical trials testing the efficacity of novel therapies in these patients. New immune approaches such as B-cell maturation antigen (BCMA) and G protein-coupled receptor, family C, group 5, member D (GPRC5D) -targeting agents, including chimeric antigen receptor (CAR) T-cells and bispecific antibodies could play a role in PCL treatment.

Age at First Fracture and Later Fracture Risk in Older Adults Undergoing Osteoporosis Assessment.

Importance: Fragility fractures are often defined as those that occur after a certain age (eg, 40-50 years). Whether fractures occurring in early adulthood are equally associated with future fractures is unclear.

Objective: To examine whether the age at which a prior fracture occurred is associated with future fracture risk.