Publications by authors named "S N METCALFE"

Article Synopsis
  • * This tool is based on data from multiple sources, including the Canadian Institute for Health Information and various health surveys and vital statistics databases.
  • * The recent update includes the addition of five new indicators and modifications to three existing ones, enhancing the tool’s coverage across four key health domains: health behaviours, health services, maternal outcomes, and infant outcomes.
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A health workforce capable of implementing genomic medicine requires effective genomics education. Genomics education interventions developed for health professions over the last two decades, and their impact, are variably described in the literature. To inform an evaluation framework for genomics education, we undertook an exploratory scoping review of published needs assessments for, and/or evaluations of, genomics education interventions for health professionals from 2000 to 2023.

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Implementation of genomic medicine into healthcare requires a workforce educated through effective educational approaches. However, ascertaining the impact of genomics education activities or resources is limited by a lack of evaluation and inconsistent descriptions in the literature. We aim to support those developing genomics education to consider how best to capture evaluation data that demonstrate program outcomes and effectiveness within scope.

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Article Synopsis
  • - Glioblastoma (GBM) is the most aggressive brain cancer, largely driven by glioblastoma stem cells (GSCs) which contribute to its recurrence and make treatment difficult.
  • - Natural killer (NK) cells have potential against GSCs but struggle with effectiveness in the GBM environment due to limited infiltration.
  • - This study presents new image-based assays to evaluate NK cell movement and ability to kill GSCs, aiming to enhance NK cell immunotherapy for better GBM management.
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Tarsal coalition occurs in 1% of the population and represents a congenital failure of segmentation in two or more tarsal bones. It most commonly occurs at the talocalcaneal and calcaneonavicular joint. Although commonly asymptomatic, it may present with pain, rigidity, and pes planus.

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