Comparative Characteristics of Anti-depressant, Anti-hypoxic Action, and Effect on the Physical Endurance of Drugs.

Objectives: The influence of original drugs from (SB) Georgi (dry extract, powder of rhizomes and roots, tablets "Scutex" on the basis of the dry extract and capsules "Scutella", which contain powder of rhizomes with roots) was studied on depressive behavior, physical endurance and anti-hypoxic activity in mice.

Materials And Methods: The used dry extract SB (SBDE), powder of roots and rhizomes from SB (SBRP), tablets from dry extract of SB named "Scutex", and hard gelatin capsules from the crushed root of SB named "Scutella" were obtained from National University of Pharmacy, Department of Industrial Technology of Drugs. In the experiment, 94 random-breed white male mice weighing 20-29 g were used and kept in standard sanitary and laboratory conditions.

[Study of specific activity of tincture "Venoton"].

The specific activity of the complex was investigated by infusion. Established that the plant complex has a pronounced anti-inflammatory effect on the model of the rat formalin edema, affecting exudative phase of inflammation. It is shown that the drug has a pronounced effect on the permeability of blood vessels and for this indicator exceeds the drug comparison aescusan.

[Glutathione metabolism in rat cardiac tissues in acute doxorubicin-induced intoxication].

Experimental data are presented on the influence of acute doxorubicin intoxication with 7.47 and 2.34 mg/kg body mass on glutathione metabolism in cardiac tissues of albino non-inbred rats.

[Correction of free radical processes by a succinic acid drug (reamberine) in intensive care of patients with acute neurotropic poisoning].

Sixty-six patients with acute poisonings with neurotropic toxins (soporiphics, neuroleptics, antidepressants, ethanol and its surrogates) were examined and treated. Clinical data and correction of disorders in free-radical processes in acute poisonings with these toxins indicate the efficiency of adding reamberine to combined therapy of this patient population.

[The glutathione-dependent antioxidant system in rats during acute intoxication by hydrazine].

Intensity of lipid peroxidation in the liver, kidney and brain tissues, and functioning of the glutathione system were studied in purebred rats after acute intoxication by 1.1-dimethyl hydrazine at the dose of 104.5 mg/kg of body mass (LD50) and phenyl hydrazine at the dose of 170 mg/kg of body mass (LD50).