HIV-1 transcription start sites usage and its impact on unspliced RNA functions in people living with HIV.

HIV-1 unspliced RNA serves two distinct functions during viral replication: it is packaged into particles as the viral genome, and it is translated to generate Gag/Gag-Pol polyproteins required for virus assembly. Recent studies have demonstrated that in cultured cells, HIV-1 uses multiple transcription start sites to generate several unspliced RNA species, including two major transcripts with three and one 5' guanosine, referred to as 3G and 1G RNA, respectively. Although nearly identical, 1G RNA is selected over 3G RNA to be packaged as the virion genome, indicating that these RNA species are functionally distinct.

Relationship between functional independence and community integration of people with spinal cord injury in Bangladesh.

Design: Prospective, cross-sectional study.

Objectives: To determine the functional outcome and home and social integration of people who had spinal cord injury and completed their inpatient rehabilitation.

Setting: Centre for the Rehabilitation of the Paralysed (CRP), Bangladesh.

Analysis of the thermal distribution of a porous radial fin influenced by an inclined magnetic field with neural computing.

Fins and radial fins are versatile engineering components that significantly enhance heat transfer and thermal management in diverse applications, hence improving efficiency and performance across several sectors. This study examines the temperature distribution in a radial porous fin under steady-state conditions, evaluating the impact of several significant parameters by utilizing a novel methodology. We specifically introduce an inclined magnetic field and examine the effects of convection and internal heat generation on the thermal behavior of the fin.

Evaluating Active Learning Strategies for Automated Classification of Patient Safety Event Reports in Hospitals.

Patient safety event (PSE) reports, which document incidents that compromise patient safety, are fundamental for improving healthcare quality. Accurate classification of these reports is crucial for analyzing trends, guiding interventions, and supporting organizational learning. However, this process is labor-intensive due to the high volume and complex taxonomy of reports.

Role of mordants in natural fabric dyeing and their environmental impacts.

The textile industry is undergoing a transformative shift towards sustainability, driven by mounting environmental concerns and consumer demand for eco-friendly products. This review article explores the use of mordants in textile dyeing processes, encompassing both traditional metal mordants and emerging bio-mordants. Metal mordants, commonly used in textile dyeing, present environmental challenges due to their toxic nature.