Publications by authors named "S N Hobbie"
Background: Whole genome sequencing of clinical bacterial isolates holds promise in predicting their susceptibility to antibiotic therapy, based on a detailed understanding of the phenotypic manifestation of genotypic variation. The ' aminoglycoside acetyltransferase gene family is the most abundant aminoglycoside resistance determinant encountered in clinical practice. A variety of AAC(6') isozymes have been described, suggesting a phenotypic distinction between subtype I, conferring resistance to amikacin (AMK), and subtype II, conferring resistance to gentamicin (GEN) instead.
View Article and Find Full Text PDFAnthropogenic nitrogen (N) deposition is unequally distributed across space and time, with inputs to terrestrial ecosystems impacted by industry regulations and variations in human activity. Soil carbon (C) content normally controls the fraction of mineralized N that is nitrified (ƒ), affecting N bioavailability for plants and microbes. However, it is unknown whether N deposition has modified the relationships among soil C, net N mineralization, and net nitrification.
View Article and Find Full Text PDFObjectives: The use of mouse models of complicated urinary tract infection (cUTI) has usually been limited to a single timepoint assessment of bacterial burden. Based on longitudinal in vitro and in vivo data, we developed a pharmacokinetic-pharmacodynamic (PKPD) model to assess the efficacy of apramycin, a broad-spectrum aminoglycoside antibiotic, in mouse models of cUTI.
Methods: Two Escherichia coli strains were studied (EN591 and ATCC 700336).
Article Synopsis
- Rising levels of carbon dioxide (CO2) and nitrogen (N) in the atmosphere impact plant communities, with nitrogen deposition leading to local biodiversity loss.
- An open-air experiment over 24 years showed that while nitrogen initially had a smaller effect on species richness at higher CO2 levels, this reversed over time, with elevated CO2 increasing the negative impact of nitrogen on plant diversity.
- The study suggests that increased levels of CO2 could worsen the detrimental effects of nitrogen on grassland biodiversity, raising concerns for global conservation efforts.