Using computational video analysis in ageing mice to evaluate the effects of chronic monotherapy, polypharmacy and deprescribing over time.

Background: In clinical studies of older adults, polypharmacy (use of ≥ 5 drugs) and the Drug Burden Index (DBI; measures exposure to anticholinergic and sedative drugs) are associated with impaired physical function and frailty. We used computational video analysis of aging mice to examine the impact of medications on morphometric and gait function.

Methods: Middle-aged (12 month) male mice were administered therapeutic doses of medications in polypharmacy regimens with different DBI scores or monotherapy with medications from the High DBI polypharmacy regimen.

Feasibility of Measuring Physical Function by Wearable Devices During Deprescribing of Anticholinergic and Sedative Medicatiossns.

Cumulative exposure to anticholinergic and sedative medications has been associated with worsening physical function in older adults. We evaluated the feasibility of measuring physical function using wearable devices and explored the impact of reducing the anticholinergic and sedative medication burden in a pilot study of community-dwelling adults aged 60 years and older. Evaluations included the 10-meter walk test (10MWT), the Short Physical Performance Battery (SPPB), and the mini-BESTest.

Impact of in-hospital medication changes on clinical outcomes in older inpatients: the journey and destination.

Background: Medication review is integral in the pharmacological management of older inpatients.

Objective: To assess the association of in-hospital medication changes with 28-day postdischarge clinical outcomes.

Methods: Retrospective cohort of 2000 inpatients aged ≥75 years.

Effectiveness of the Interdisciplinary Home-bAsed Reablement Programme (I-HARP) on improving functional independence of people living with dementia: a multicentre, pragmatic, randomised, open-label, controlled trial.

Background: We investigated the effectiveness of an Interdisciplinary Home-bAsed Reablement Programme (I-HARP) on improving functional independence, health and well-being of people with dementia, family carer outcomes and costs.

Method: A multicentre pragmatic parallel-arm randomised controlled trial compared I-HARP to usual care in community-dwelling people with mild to moderate dementia and their family carers in Sydney, Australia (2018-2022). I-HARP is a 4-month, home-based, dementia rehabilitation model delivered by an interdisciplinary team.

Integrated solutions for sustainable fall prevention in primary care: a pragmatic hybrid-type 2 mixed methods implementation and effectiveness study.

Unlabelled: The iSOLVE implementation project established and evaluated integrated processes and pathways, including a decision-making tool and educational interventions for general medical practitioners (GPs) and the upskilling of allied health professionals (AHPs). The study used a mixed-methods (parallel) design comprising surveys, qualitative methodologies, and an embedded cluster randomized controlled trial (RCT). Sampling was conducted within a Primary Health Network (PHN) geographic area in Sydney, Australia.