[Synthesis and biological properties of delta-sleep peptide analogs. 2. Antimetastatic effect].

With the aim to investigate structure-functional relations of DSIP, 11 DSIP analogues were tested on antimetastatic activity, among them five new analogues, differing in positions 2 and 6 of the DSIP amino acid sequence were synthesized by the solid-phase method using Fmoc-approach. Experiments on C57B1 mice with metastatic Lewis lung carcinoma showed some analogues to be more efficient as antimetastatic agents then DSIP after i.v.

[Effects of prostaglandins E2 and F2 alpha on the hypothalamo-hypophyseal-adrenal system and thyroid function in mice with Lewis lung carcinoma].

It has been determined that prostaglandins E2 and F2 alpha being exogenously inoculated during the premetastatic period to mice with metastatic Lewis lung carcinoma in equal degree activate neurocytes of supraoptic and paraventricular hypothalamus nuclei, playing the important role in secretion of peptidergic hypophysial adrenal gland complex, but they exert unequal influence on pituitary body, adrenal cortex and thyroid apparatus. F2 alpha stimulates the pituitary body corticotrophic function, secretory function of spongiocytes and thyrocytes, identifies the thyroxin and triiodothyronine utilization, E2, on the contrary, does not influence these indices or reduces them. Obviously, the mentioned above differences between E2 and F2 alpha may be explained by their different influences on antimetastatic resistance.

[Effect of prostaglandins on metastatic spread after surgical removal of tumors and pain stress in mice].

The effect of prostaglandins (PG) E2 and F2 alpha, indomethacin and arachidonic acid on stressful metastatic stimulation observed in case of combined stress influence has been studied in C57Bl mice with Lewis carcinoma. Under conditions of excessive stress load indomethacin, arachidonic acid and PGF2 alpha stimulated the development of metastases, while PGE2 caused an inhibiting effect. On the contrary, in animals which were not affected by stress indomethacin and PGF2 alpha revealed an antimetastatic effect.

[Changes in neurohumoral factors of various tissues in patients with breast cancer].

Such neurohumoral factors of antitumor resistance regulation as catecholamines, corticosteroids and cholinergic mechanisms were studied in tissues of breast cancer patients. Tissue adjacent to tumor revealed elevated concentrations of 11-hydroxycorticosteroids and adrenaline matched by an increased release of norepinephrine which greatly depended on weakened cholinergic influences. These disturbances were pronounced in stages I and II tumors and, particularly, in infiltrating scirrhous cancer.