Publications by authors named "S N Danilov"
[Heavy eye syndrome: clinical manifestations, diagnosis and treatment].
Vestn Oftalmol
November 2024
Article Synopsis
- Heavy eye syndrome (HES) is a unique type of strabismus caused by a significant elongation of the eye's axial length, leading to misalignment and reduced eye movement, often seen in patients with high myopia.
- Identification of HES relies on multislice computed tomography (MSCT), which reveals a key sign of the condition: the dislocation of the posterior pole from the muscle cone.
- The preferred surgical option for HES involves techniques that reposition the superior and lateral rectus muscles, as traditional surgeries are less effective and may complicate future treatment.
Introduction: Several techniques are used for laser enucleation of benign prostate hyperplasia, including two- and three-lobe enucleation, enucleation of all lobes in a single block (en-bloc), and enucleation of all nodes in a single block without longitudinal incisions (total en-bloc).
Aim: A prospective and retrospective analysis of the results of two-lobe, en-bloc, and total en-bloc using thulium fiber laser enucleation of the prostate (ThuFLEP) techniques was performed.
Method: s.
Article Synopsis
- Recent analysis identified over 400 damaging missense ACE mutations, suggesting that carriers of heterozygous loss-of-function ACE mutations may be at risk for late-onset Alzheimer's disease (AD).
- A study measuring blood ACE levels in 41 subjects with different heterozygous mutations revealed that certain mutations (Y215C and G325R) significantly reduced ACE levels, while the R1250Q mutation did not impact ACE levels.
- The findings indicate that measuring blood ACE levels in patients with ACE mutations could help identify those at increased risk for AD, potentially guiding future preventive treatments involving chaperones and proteasome inhibitors to improve ACE function.
Article Synopsis
- Researchers hypothesized that individuals with damaging mutations of the Angiotensin-I-Converting Enzyme (ACE) and low ACE levels may be at risk for late-onset Alzheimer’s disease (AD).
- The study analyzed blood ACE levels in 15 patients with various mutations and confirmed that a common mutation (Y215C) is linked to reduced ACE levels and AD risk.
- Additional mutations were identified that also correlated with decreased ACE levels, suggesting potential risk factors for AD; the research indicates that identifying these mutations may help target individuals who could benefit from specific therapeutic treatments.
Myasthenia gravis is an autoimmune disease characterized by muscle weakness and pathological fatigue due to autoaggressive phenomena with the formation of antibodies directed against various structures of the neuromuscular synapse. In most patients, the disease begins with the involvement of extraocular muscles, presenting with symptoms such as intermittent ptosis of the upper eyelid and/or binocular diplopia. In 15% of cases, clinical manifestations are limited to impairment of the levator palpebrae superioris and extraocular muscles, characteristic of the ocular form of myasthenia gravis.
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