Publications by authors named "S N Constantinescu"
Orthopedic screws are subjected to high mechanical stress, corrosive environment, and microbial colonization, which may cumulatively lead to implant failure and periprosthetic joint infections. To overcome these issues, this study has focused on modifying the surface chemistry and topography of screws utilized in knee intervention toward enhancing their mechanical and biological behaviors. Specifically, this study has explored the optimization of composite coatings made of polycaprolactone (PCL), graphene oxide (GO), and Meropenem (MRP) via the matrix-assisted pulsed laser evaporation (MAPLE) technique.
View Article and Find Full Text PDFThe consequences of unintended pregnancy in recipients of liver transplants (LTs), a growing part of the high-risk obstetric population, remain unknown. To fill this gap, we conducted a retrospective registry cohort study to describe the risk factors, obstetric and neonatal morbidity, and graft outcomes associated with unintended pregnancy after LT. This study utilized the Transplant Pregnancy Registry International and included 565 pregnancies of recipients of LT between 1967 and 2019 from 289 hospitals, primarily in North America.
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- Pituitary adenomas (PA), or Pit-NETS, are rare in children and especially unusual in those under 10, with the majority of research conducted on adult cases.
- This review addresses the unique clinical considerations, diagnosis, and treatment of PA in young patients, highlighting the importance of involving specialized teams that include both pediatric and adult medical experts.
- Pediatric PAs tend to be larger, more aggressive, and often lead to hormonal imbalances that can affect growth and puberty, with the most common type being prolactinomas; genetic testing is recommended for young patients due to potential hereditary mutations linked to these tumors.
Article Synopsis
- Oxazolidinones, like linezolid and tedizolid, can cause adverse reactions, particularly thrombocytopenia, due to their impact on mitochondrial function, though the exact mechanism is still unclear.
- * In experiments with human CD34+ cells, oxazolidinones significantly reduced burst-forming unit-erythroid (BFU-E) colony formation and disrupted the differentiation of megakaryocytes, affecting their typical maturation and structure.
- * The toxicity observed was more severe with tedizolid compared to linezolid, suggesting that mitochondrial dysfunction plays a crucial role in thrombocytopenia, which complicates potential pharmacological solutions for this side effect.