'Parents Are the First Tutors of Their Child': Parents' Perception of Responsibility on Practicing Speech-Language Home Program During COVID-19 Lockdown.

Background And Objectives: Some families faced difficulties accessing speech therapy in some areas of Malaysia and/or during the COVID-19 lockdown. Therefore, parent-mediated intervention could be one of the ways to solve this issue, as it has been proven to effectively improve communication skills among children with communication disorders. Hence, a Mandarin parental guidebook comprising a series of language stimulation activities was developed to explore the perception of parents of children with communication disorders, ranging from 3 to 6 years old, regarding the feasibility of (1) conducting speech-language home programs and (2) using a home-based parental guidebook as a tool to deliver a speech-language home program.

Ascending-to-Descending Aortic Bypass of a Thoracic Stent Graft Infection with a Rare Pathogen.

Stent graft infection (SGI) caused by complex is rare. The usage of ascending-to-descending aortic bypass (ADAB) in such situations has not yet been fully discussed. Case report and literature review.

The pathogenesis of depression: Roles of connexin 43-based gap junctions and inflammation.

Background: Depression is a leading chronic mental illness worldwide, characterized by anhedonia and pessimism. Connexin is a kind of widely distributed protein in the body. Connexin 43 (Cx43) plays an important role in the pathogenesis of depression.

Multilingualism and developmental language disorder in Southeast Asian speech-language pathology practice: An international survey.

Purpose: This study aims to explore the current practices and challenges faced by speech-language pathologists in three Southeast Asian countries (Malaysia, Indonesia, and Vietnam) in assessing and treating multilingual children with developmental language disorder.

Method: A survey was designed and administered to 110 speech-language pathologists across Malaysia, Indonesia, and Vietnam. The survey contained 60 questions on current practices and knowledge of existing resources for assessing and treating multilingual children with developmental language disorder.

PRMT5-Mediated ALKBH5 Methylation Promotes Colorectal Cancer Immune Evasion via Increasing CD276 Expression.

Numerous diseases have been connected to protein arginine methylations mediated by protein arginine methyltransferase 5 (PRMT5). Clinical investigations of the PRMT5-specific inhibitor GSK3326595 are currently being conducted, and the results are promising for preventing cancers. However, the detailed mechanism of PRMT5 promoting colorectal cancer (CRC) malignant progression remains unclear.