Cross-facility absolute charge calibration of scintillating screens for laser wakefield accelerated beam diagnostics.

Scintillation screens are widely used to diagnose high-charge density, low-average current electron beams from laser wakefield accelerators (LWFAs). However, the absolute response between emitted photons and electron charge has only been calibrated at a limited number of facilities, and there have been discrepancies between these calibrations. In this report, we comprehensively revised the absolute charge calibration of two high relative brightness scintillating screens of LANEX Regular (Carestream) and PI200 (Mitsubishi) by employing the high-brightness photoinjector at the National Synchrotron Radiation Research Center (NSRRC), which provides electron beams with variable charges (50-350 pC per pulse) and energies (26.

The effects of cannabinoid agonism on auditory discrimination.

Recent evidence suggests that cannabis can impair simple auditory processes, and these alterations might be due to cannabinoid agonism. The effect of cannabinoid agonism on relatively complex processes such as auditory discrimination is unknown. The goal of this study was to examine the impact of WIN 55,212-2, a CB1 receptor and CB2 receptor agonism, on auditory discrimination using a go/no-go task.

Potassium escaping balances the degree of graphitization and pore channel structure in hard carbon to boost plateau sodium storage capacity.

Biomass holds significant potential for large-scale synthesis of hard carbon (HC), and HC is seen as the most promising anode material for sodium-ion batteries (SIBs). However, designing a HC anode with a rich pore structure, moderate graphitization and synthesis through a simple process using a cost-effective precursor to advance SIBs has long been a formidable challenge. This is primarily because high temperatures necessary for pore regulation invariably lead to excessive graphitization.

Efficacy, safety, and quality of life 4 years after valoctocogene roxaparvovec gene transfer for severe hemophilia A in the phase 3 GENEr8-1 trial.

Background: Valoctocogene roxaparvovec, an adeno-associated virus-mediated gene therapy for severe hemophilia A, enables endogenous factor (F)VIII expression and provides bleed protection.

Objectives: Determine valoctocogene roxaparvovec durability, efficacy, and safety 4 years after treatment.

Methods: In the phase 3 GENEr8-1 trial, 134 adult male persons with severe hemophilia A without inhibitors and previously using FVIII prophylaxis received a 6 × 10 vg/kg infusion of valoctocogene roxaparvovec.

One-Pot and Gram-Scale Synthesis of Fe-Based Nanozymes with Tunable O Activation Pathway and Specificity Between Associated Enzymatic Reactions.

Nanozymes have recently gained attention for their low cost and high stability. However, unlike natural enzymes, they often exhibit multiple enzyme-like activities, complicating their use in selective bioassays. Since HO and O are common substrates in these reactions, controlling their activation-and thus reaction specificity-is crucial.