Development of a Preliminary Patient Safety Classification System for Generative AI.

Generative artificial intelligence (AI) technologies have the potential to revolutionise healthcare delivery but require classification and monitoring of patient safety risks. To address this need, we developed and evaluated a preliminary classification system for categorising generative AI patient safety errors. Our classification system is organised around two AI system stages (input and output) with specific error types by stage.

Basic Science and Pathogenesis.

Background: Chronic, excessive alcohol consumption causes neurodegeneration and is associated with an increased risk for Alzheimer's disease (AD) and other dementias. Moreover, there has been a consistent rise in alcohol consumption in older adults in the past few decades. However, there is minimal research showing how alcohol consumption affects AD neuropathogenesis and biological mechanisms remain unclear.

Updating probability of pathogenicity for RYR1 and CACNA1S exon variants in individuals without malignant hyperthermia after exposure to triggering anesthetics.

Objectives: We aimed to classify genetic variants in RYR1 and CACNA1S associated with malignant hyperthermia using biobank genotyping data in patients exposed to triggering anesthetics without malignant hyperthermia phenotype.

Methods: We identified individuals who underwent surgery and were exposed to triggering anesthetics without malignant hyperthermia phenotype and who had RYR1 or CACNA1S genotyping data available in our biobank. We classified all variants in the cohort using a Bayesian framework of the American College of Medical Genetics and Genomics and the Association of Molecular Pathologists guidelines for variant classification and updated the posterior probabilities from this model with the new information from our biobank cohort.

Solution-Focused Brief Therapy for Improving Couple Dyadic Relationships in Iran: A Systematic Review.

Despite the popularity of Solution-Focused Brief Therapy (SFBT) in Iran, the existing literature synthesis has limitations due to the reliance on studies published primarily in Farsi. This systematic review addresses these gaps by synthesizing and evaluating the effectiveness of SFBT on the marital outcomes of couples in Iran, incorporating both Farsi and English sources. The search for this review yielded 1523 records, from which 26 randomized controlled trials were included.