[Anemia in patients with chronic cardiac failure].

The number of patients with chronic cardiac failure (CCF) grows continuously in the last decades especially among aged subjects compared with younger ones. Mortality and hospitalization rates among elderly subjects are also higher Hence, the importance of early diagnosis and treatment of concomitant diseases aggravating CCF, e.g.

[The technologies of genetic engineering in treatment of chronic lower limb ischemia].

The article contains experimental data on angiogenesis stimulated by plasmid containing the angiogenin gene. After the introduction of the gene construction, the number of capillars in the chorion-allantois membrane increases 2 to 3 times; in an ischemized limb of a rat it increases by 20 to 30%. Intramuscular administration of genetic engineering construction to patients with chronic lower limb ischemia improved the patients' condition, consisting in an increase in painless walking distance and ankle-brachial index, as well as in trophic defect healing and the betterment of muscular perfusion.

Human angiogenin lacks specific antimicrobial activity.

The antimicrobial activities of commercially available human angiogenin were studied against two pathogens, namely, Candida albicans and Streptococcus pneumoniae. In contrast to the data published earlier, antimicrobial action of angiogenin was rather limited and comparable to that of bovine serum albumin.

[The CELO-ANG recombinant avian adenovirus with human angiogenine gene inducing neovascularization in the anterior tibial muscle of rat].

The CELO recombinant avian adenovirus carrying the gene coding the human angiogenine (ANG) synthesis was obtained. Expression of the angiogenine gene was shown in the LMH cell culture after infection with the CELO-ANG virus. The ability of CELO recombinant adenoviruses to carry out the delivery and expression of alien genes in muscle cells was demonstrated in experiments with laboratory animals (Wistar line rats).

[Optimization of therapeutic and diagnostic processes in the system of obligatory medical insurance in an outpatient ENT department].

How to organize effective activity of an outpatient ENT department in the system of obligatory medical insurance (OMI) is considered. To achieve this purpose, an analysis of everyday activity of an outpatient department was made with estimation of reference morbidity, epidemiological data on the residents of the Central Moscow District. Measures for introduction of novel technologies in therapeutic outpatient ENT practice are proposed.