[Use of perftoran in complex treatment of acute pancreatitis].

Efficiency of using perftoran in acute pancreatitis was determined by studying the dynamics of the level of lactic acid, ascorbic acid, one of the terminal metabolites of lipid peroxidation--TBA-active products in blood serum. Using perftoran was shown to considerably reduce manifestations of hypoxia and the degree of free radical processes that is evidence of antiischemic effect of perftoran in treatment of acute pancreatitis.

[The effect of adaptation to the periodic action of hypoxia on the indices of the immunity system and on the course of allergic diseases].

The authors studied the effect of adaptation to periodical exposure to hypoxia on the organism's immune status and the values of neurohumoral regulation in children with bronchial asthma and adults suffering from allergic dermatoses and autoimmune thyroiditis. It was found that adaptation facilitated normalization of humoral values of immunity in allergic and autoimmune disorders (the content of serum immunoglobulins increased while the level of circulating immune complexes reduced) and was attended by a stable therapeutic effect. The revealed changes of the immune values occurred in increase of the reserve potency of the hypothalamo-hypophyseal-adrenal and sympathoadrenal systems and reduction of the blood histamine level.

[Determination of liver cholesterol-7 alpha-monooxygenase activity in an in vivo experiment].

The method of determination of cholesterol-7 alpha-monooxygenase activity in vivo which has a number of advantages over the existing ones is offered. [3H]cholesterin was injected into rats intravenously in the form of albumin-stabilized emulsion. In 2--4 h and then every day 3H2O radioactivity of one of the cholesterin enzymatic hydroxylation products in microsomal liver apparatus was estimated in animals' urine.

[Use of functional indices of the erythron system in the diagnosis of alcoholism].

A study was made of indices of the erythron system in 137 alcoholic patients (stages I, II, III). At all 3 stages a rise of the level of intraerythrocytic 2,3-DPG in erythrocytes and a serum erythropoietic titer was detected, at II and III stages--reticulocytosis and erythrocytic life reduction, and at III stage--a decrease in the number of erythrocytes. The results indicated the involvement of the erythron system in the compensation of changes developing in alcoholism, first of all hypoxia.