Prednisolone at a therapeutic dose is not detrimental to mouse oocyte competence.

Objective: To examine the impact of PRDL on mouse oocyte developmental competence.

Methods: This study was conducted on 6-8-week-old female Swiss albino mice in which different doses of PRDL were administered for three days during superovulation. Oocytes were assessed for quality, and subsequently, embryos derived from these oocytes were evaluated at the blastocyst stage.

Advancements in Breathomics: Special Focus on Electrochemical Sensing and AI for Chronic Disease Diagnosis and Monitoring.

This Review examines the potential of breathomics in enhancing disease monitoring and diagnostic precision when integrated with artificial intelligence (AI) and electrochemical sensing techniques. It discusses breathomics' potential for early and noninvasive disease diagnosis with a focus on chronic kidney disease (CKD), chronic obstructive pulmonary disease (COPD), and lung cancer, which have been well studied in the context of VOC association with diseases. The noninvasive nature of exhaled breath analysis can be advantageous compared to traditional diagnostic methods for CKD, which often rely on blood and urine testing.

Functional characterization of tRNA-derived small RNAs in stem cells.

Transfer RNA (tRNA)-derived RNAs (tDRs) are abundant small RNAs with emerging roles in development and tumorigenesis. Increasing evidence indicates that tDRs regulate stem cell homeostasis and differentiation, often altered in disease, highlighting the importance of fully characterizing their role in stem cell biology. Multiple studies point to protein synthesis as a crucial target of tDR-mediated control of different stem cell types.

RNA in Stow, Leukemia on the Go: P-Bodies RNA Sequestration Drives Leukemogenesis.

A novel mechanism of sequestering tumor suppressor mRNAs reveals new therapeutic vulnerabilities in leukemic cells.

A novel sweat sensor detects inflammatory differential rhythmicity patterns in inpatients and outpatients with cirrhosis.

Patients with cirrhosis have high systemic inflammation (TNFα, CRP, and IL-6) that is associated with poor outcomes. These biomarkers need continuous non-invasive monitoring, which is difficult with blood. We studied the AWARE sweat-sensor to measure these in passively expressed sweat in healthy people (N = 12) and cirrhosis (N = 32, 10 outpatients/22 inpatients) for 3 days.