Publications by authors named "S Murtough"
Article Synopsis
- * A new shape-changing haptic interface (Shape) was tested, showing that individuals with VI were able to locate virtual targets much faster and more efficiently using Shape compared to traditional vibration feedback.
- * Shape received better user experience ratings than vibration feedback, and its performance matched that of natural vision, indicating potential for this technology in enhancing navigation for those with VI.
Article Synopsis
- Survival rates for esophageal squamous cell carcinoma (ESCC) are low due to late diagnosis, prompting research into early molecular changes that could aid in earlier detection.
- The study examined esophageal biopsies from individuals with Tylosis with esophageal cancer (TOC), a syndrome linked to higher ESCC risk, identifying significant transcriptional changes that were also seen in ESCC.
- Results indicated that these early changes may be crucial in understanding how sporadic ESCC develops and highlighted specific upregulated genes like Keratin 17 that could serve as potential biomarkers.
Article Synopsis
- The study investigates differences in immune cell signatures and sensory markers in various reflux disease phenotypes compared to healthy subjects.
- Thirty-seven patients were categorized into four groups (ERD, NERD, FH, and BO) and their tissue samples analyzed through mRNA sequencing and immunofluorescent staining.
- Results showed increased mast cell abundance and decreased dendritic cell infiltration in GERD patients, along with higher nerve growth factor expression in mast cells, indicating potential mechanisms for esophageal sensitivity and immune response development.
The study of a desmoglein 2 murine model of arrhythmogenic cardiomyopathy revealed cardiac inflammation as a key early event leading to fibrosis. Arrhythmogenic cardiomyopathy (AC) is an inherited heart muscle disorder leading to ventricular arrhythmias and heart failure due to abnormalities in the cardiac desmosome. We examined how loss of desmoglein 2 (Dsg2) in the young murine heart leads to development of AC.
View Article and Find Full Text PDFThe palmoplantar epidermis is a specialized area of the skin that undergoes high levels of mechanical stress. The palmoplantar keratinization and esophageal cancer syndrome, tylosis with esophageal cancer, is linked to mutations in RHBDF2 encoding the proteolytically inactive rhomboid protein, iRhom2. Subsequently, iRhom2 was found to affect palmoplantar thickening to modulate the stress keratin response and to mediate context-dependent stress pathways by p63.
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