[Activated protein C resistance in patients with venous leg ulcer].

Patients with venous leg ulcers often show evidence of previous deep venous thrombosis. Resistance to activated protein C (APC-resistance) is an autosomal dominant inherited defect in the anticoagulant system which is a significant risk factor for development of venous thrombosis. APC-resistance was determined in plasma samples obtained from 46 unselected, consecutively admitted patients with venous leg ulcers, included during a six-month period.

[Copper-induced green hair. Treatment with a penicillamine containing shampoo].

A male patient with green hair is described. The cause was exogenous deposition of copper from domestic tap water which contained an increased copper concentration. The discolouration disappeared promptly following the use of a penicillamine containing shampoo.

Resistance to activated protein C: a common anticoagulant deficiency in patients with venous leg ulceration.

Patients with leg ulcers caused by venous insufficiency often show evidence of previous deep venous thrombosis. Resistance to activated protein C (APC resistance) is a newly identified, autosomal dominant inherited defect in the anticoagulant system which significantly predisposes affected individuals to develop venous thrombosis. To elucidate the significance of APC resistance in venous leg ulcer patients, APC resistance was determined in plasma samples obtained from 46 unselected, consecutive patients with venous leg ulcers, admitted to hospital during a 6-month period.