Publications by authors named "S Mullamitha"
PICO-SM was a prospective longitudinal study investigating the psychological impact of the COVID-19 pandemic on patients with colorectal cancer treated in a large UK tertiary cancer centre. Here, we present the impact of the third wave of the pandemic (December 2021 to February 2022), when the Omicron variant became prevalent in the UK, and the complete longitudinal comparison across the entire duration of this study. Patients were invited to complete a questionnaire, including screening psychometric tools.
View Article and Find Full Text PDFArticle Synopsis
- Early onset colorectal cancer (EOCRC), affecting individuals under 50, has seen a significant rise in cases since 1970, with a notable increase from 2018-2019 to 2020-2021, highlighting a lack of data in the UK about this condition.
- A study analyzing 203 EOCRC patients over 9 years revealed that most cases were sporadic, two-thirds had left-sided tumors, and many presented with metastatic disease, resulting in a median overall survival of 38 months and a median progression-free survival of 6 months.
- The findings advocate for increased public awareness, earlier screening recommendations, and more extensive research to enhance understanding and management of EOCRC.
Treatment guidelines provided by PRODIGE-7 recommend perioperative systemic chemotherapy before cytoreductive surgery (CRS) for colorectal cancer peritoneal metastases (CRPM). Toxicity with multimodal treatment needs to be better defined. Chemotherapy response and impact on survival have not been reported.
View Article and Find Full Text PDFBackground: Appendix adenocarcinomas (AAs) are rare tumours that often present late, with a propensity for peritoneal metastases (PMs). This study aimed to evaluate outcomes of AA patients undergoing cytoreductive surgery (CRS) with curative intent and determine the role of systemic chemotherapy.
Materials And Methods: Data were collected from a prospective database and classified according to World Health Organization (WHO) 2019 classification.
The multi-societal European consensus on the terminology, diagnosis and management of patients with synchronous colorectal cancer and liver metastases: an E-AHPBA consensus in partnership with ESSO, ESCP, ESGAR, and CIRSE.
HPB (Oxford)
September 2023
Article Synopsis
- This project developed a framework for managing patients with synchronous colorectal cancer and liver metastases, addressing terminology, diagnosis, and treatment strategies.* -
- A multi-organizational consensus was reached through a Delphi process, resulting in twelve key statements with at least 70% agreement on issues like treatment pathways and tumor board composition.* -
- Key findings include definitions for metastases timing, guidelines for clinical assessments, and recommendations for various treatment approaches, aimed at improving clinical practice for affected patients.*