Publications by authors named "S Mukundan"
Background: Lam. (Moringaceae) is an indigenous tree extensively used as a nutrient and an antioxidant. In addition to its medicinal attributes, it possesses a promising role in moisturizing and cleansing the skin.
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- * They focused on adult education fundamentals, necessary training for high-quality patient care, and emphasized diversity, equity, and inclusion.
- * The resulting paper serves as a guide for trainees, providing insights on the current state of critical care cardiology and outlining future directions for the field’s growth.
High-affinity biomolecular interactions are modulated by low-affinity binders.
NPJ Syst Biol Appl
August 2024
The strength of molecular interactions is characterized by their dissociation constants (K). Only high-affinity interactions (K ≤ 10 M) are extensively investigated and support binary on/off switches. However, such analyses have discounted the presence of low-affinity binders (K > 10 M) in the cellular environment.
View Article and Find Full Text PDFThe extracellular matrix (ECM) is a critical component of tissue where it provides structural and signaling support to cells. Its dysregulation and accumulation lead to fibrosis, a major clinical challenge underlying many diseases that currently has little effective treatment. An understanding of the key molecular initiators of fibrosis would be both diagnostically useful and provide potential targets for therapeutics.
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- A study has been conducted to identify new drug targets to combat a highly lethal pathogen causing tuberculosis, focusing on essential proteins like biotin synthase and alpha-(1->6)-mannopyranosyltransferase A involved in specific biosynthesis pathways.
- Researchers used bioinformatics tools to model proteins without native structures and explored interactions with natural compounds derived from selected mushrooms.
- Out of 15 identified bioactive compounds, four were chosen for further analysis, with Benz[e]azulene showing promising binding affinity to a specific target, indicating the potential of mushroom extracts in developing new TB treatments.