Background: Lam. (Moringaceae) is an indigenous tree extensively used as a nutrient and an antioxidant. In addition to its medicinal attributes, it possesses a promising role in moisturizing and cleansing the skin.
View Article and Find Full Text PDFNPJ Syst Biol Appl
August 2024
The strength of molecular interactions is characterized by their dissociation constants (K). Only high-affinity interactions (K ≤ 10 M) are extensively investigated and support binary on/off switches. However, such analyses have discounted the presence of low-affinity binders (K > 10 M) in the cellular environment.
View Article and Find Full Text PDFThe extracellular matrix (ECM) is a critical component of tissue where it provides structural and signaling support to cells. Its dysregulation and accumulation lead to fibrosis, a major clinical challenge underlying many diseases that currently has little effective treatment. An understanding of the key molecular initiators of fibrosis would be both diagnostically useful and provide potential targets for therapeutics.
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