Publications by authors named "S Muhammed Musthafa"
The COVID-19 pandemic has primarily been characterized by respiratory symptoms, but emerging evidence suggests multi-organ involvement, including the gastrointestinal tract. This case report aims to highlight colon perforation as a rare but significant complication in COVID-19 patients. We present two cases of male patients, aged 38 and 33, who were admitted with severe COVID-19 symptoms and required intubation and ventilator support.
View Article and Find Full Text PDFClerodane diterpene 3-deoxycaryoptinol (Clerodin) selectively induces apoptosis in human monocytic leukemia (THP-1) cells and upregulates apoptotic protein caspase-3.
Free Radic Biol Med
November 2024
Article Synopsis
- 3-deoxycaryoptinol (Clerodin), a compound from Clerodendrum infortunatum leaves, shows promising anticancer effects on human monocytic leukemia cells (THP-1).
- The research demonstrated clerodin's ability to induce apoptosis via various assays, including Annexin-V/PI for cell death and western blotting for mitochondrial apoptosis markers like caspase-3.
- Notably, clerodin specifically targets the G2/M phase of the cell cycle and exhibits minimal toxicity to healthy human blood cells, highlighting its potential as a selective chemotherapeutic agent.
Merin Yohannan Timely diagnosis of lung cancer is critical because treatment outcomes correspond to the stage of disease. This study identified patient and physician determined reasons for diagnostic delays. s This was an observational cross-sectional study, conducted at a tertiary care institution in South India, for 12 months.
View Article and Find Full Text PDFPatients with autoimmune rheumatic diseases with a previous infection by the SARS-CoV-2 virus have exaggerated responses to a single dose of COVID-19 vaccination as compared to fully vaccinated infection naive patients. The second dose is currently recommended at an extended gap after the infection, but the information available regarding response to the second dose in this subgroup is limited. Patients with AIRDs previously infected with COVID-19, who have received at least one dose of AZD1222/ChAdOx1 (n = 200) were included and stratified based on vaccine doses (V), and infection (I) into I + V, I + V + V, V + I, V + V + I.
View Article and Find Full Text PDFA 336-base pair (bp) sized mRNA sequence encoding 111 amino acid size crustin isoform (MC-crustin) was obtained from the gill sample of the green mud crab, . MC-crustin possessed an N-terminal signal peptide region comprising of 21 amino acid residues, followed by a 90 amino acid mature peptide region having a molecular weight of 10.164 kDa, charge + 4.
View Article and Find Full Text PDF